For the past 25 years, Nuala Gregory has maintained a profile as an exhibiting artist predominantly in the medium of painting, but also in printmaking and drawing. Her work has been shown in Ireland, the USA, New Zealand, Mexico, China and Japan.

Gregory is also known for her writings on contemporary art and on art education. A recipient of numerous arts grants and bursaries, she has contributed to the visual arts environment through curation, artistic collaborations, international conferences, and the enhancement of arts programmes, teaching and infrastructure in tertiary level education.